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Whitewing Labs, Inc.

Journal of Natural Health, April 2000

Steven Galen, M.D.
by Steven Galen, M.D.
Pantethine:
Cholesterol-Lowering Nutrient

While more than 30 million prescriptions for cholesterol-lowering drugs are filled annually, for all of their important benefits these drugs are not without increased risks for complications. Anyone taking cholesterol-lowering drugs should know about their risks and, when feasible, their nutritional alternatives, as well as those nutritional formulas that complement their use.
    For example, Cholest-Less from Whitewing Labs can often be extremely beneficial to persons who are attempting to try nontoxic methods for normalizing their cholesterol, In some cases, Cholest-Less can help persons to lower their dosage for cholesterol-lowering drugs or replace their drug use altogether.
    
Cholest-Less, recently reformulated, now contains several key cholesterol-lowering agents including pantethine and soy extract which was recently recognized by the Food and Drug Administration for its cholesterol-lowering benefits.

Powerful Cholesterol-Buster
Pantethine is an essential nutrient for proper fat and cholesterol breakdown. It is the biologically active form of pantothenic acid (vitamin B5).
    
Pantethine is key to the breakdown of triglycerides and normal cholesterol metabolism. It also helps to protect cholesterol from free radical damage, thus helping to keep the arteries plaque-free.

Especially For Women
Pantethine is especially helpful for women. Heart disease is the main cause of death in adult women. For many women, long-term treatment with cholesterol-lowering drugs may cause undesirable side effects (see sidebar). But pantethine has been shown to be well tolerated. In one study, researchers gave pantethine to 24 perimenopausal women, ranging in age from 45 to 55.

    After 16 weeks of treatment, significant reductions of total cholesterol, low density lipoproteins (LDLs, the bad cholesterol that causes

plaque build-up) and ratio of LDLs to high density lipoproteins (HDLs, the good cholesterol that resists oxidation) could be observed in about 80 percent of patients. None of the patients complained of adverse reactions due to the pantethine.

Helps Diabetics
Control Cholesterol
Diabetics can also benefit from Cholest-Less, thanks to its pantethine. Elevated cholesterol and triglycerides are a very frequent complication of the diabetic patient, especially those on dialysis. However, dietary changes are very often not sufficient for cholesterol control and interactions between cholesterol-lowering drugs and those for diabetes make drug treatment perilous.
    Some 37 patients with either high cholesterol or triglycerides, 21 of whom were diabetic, were given pantethine. Pantethine induced in all groups a quick and progressive decrease of cholesterol, triglycerides, and LDL cholesterol with increased HDLs. “Pantethine was shown to be a very effective hypolipemic agent in diabetic patients on dialysis with a great tolerance.”

Helps All Persons
But pantethine is just a good nutrient for anyone with high cholesterol. Pantethine was evaluated within a double-blind study with 29 patients, producing a drop of almost 14 percent in total cholesterol and LDLs. In the same patients, HDL levels increased 10 percent at the end of treatment. Switching from pantethine to placebo was associated with a rapid return to the baseline levels. Plasma triglyceride levels were reduced around 30 percent. This study provided evidence for a significant cholesterol effect from “a natural compound free of overt side effects.” It also indicated that pantethine may raise HDL levels in some, but not all, persons.
     Besides pantethine, Cholest-Less provides soy, vitamin C, niacin, magnesium, oat bran, guar gum, psyllium, garlic and l-carnitine, all of which are nutrients studied for protection against serum lipid

derangements.
    
Make Cholest-Less an important part of your safe and natural healthy heart regimen, particularly if you have high lipid levels and/or diabetes.
    
Cholest-Less is a highly effective supplement that may be used by all persons at risk for heart disease, especially perimenopausal women and diabetics, when other natural methods of lowering cholesterol do not deliver satisfactory results.
Cholesterol-Lowering Drug Nutrient Interactions

Clofibrate:Can reduce circulating levels of vitamin E and inhibit vitamin B12 absorption.

Colestipol:A bile sequestrant, colestipol can reduce blood levels of vitamin E and lead to impaired absorption of fat-soluble vitamins A, D, K and folic acid.
Statins (Lovastatin, Pravastatin, Fluvastatin, Atorvastatin, Simvastatin):
Levels of these drugs may be increased by up to 20 times when used simultaneously with consumption of grapefruit juice. These drugs can decrease the body’s levels of coenzyme Q10 by 50 percent or more. They may present increase risk of cancer.
Cholestyramine:May decrease risk of fat soluble vitamins A, D, E, and K, inhibit iron benefits and create a folic acid deficiency.


CHOLEST-LESS

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© copyright 2000 Whitewing Labs, Inc.     Last update: 26 April, 2000